Hexarelin
Hexarelin is a synthetic hexapeptide growth hormone secretagogue and an agonist of the ghrelin receptor (GHS-R1a), which is used in experimental models to investigate somatotropic and cardiovascular peptide signaling.
Research dossier
Hexarelin
Research DossierHexarelin
SequenceHis-D-Trp(2-Me)-Ala-Trp-D-Phe-Lys
FormulaC47H58N12O6
Mol. Weight887.059 g/mol
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Sequence
His-D-Trp(2-Me)-Ala-Trp-D-Phe-Lys
Molecular Formula
C47H58N12O6
Molecular Weight
887.059 g/mol
PubChem CID
6918297
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Hexarelin is a synthetic hexapeptide growth hormone secretagogue and an agonist of the ghrelin receptor (GHS-R1a), which is used in experimental models to investigate somatotropic and cardiovascular peptide signaling. In preclinical research, Hexarelin activates Gq/PLC-dependent calcium signaling pathways involved in the release of growth hormone, while at the same time it activates cardioprotective and metabolic mechanisms independent of GH secretion. Experimental studies have examined its role in the cardioprotection of the myocardium under ischemic stress, the maintenance of skeletal muscle, and the regulation of lipid metabolism through peptide-mediated endocrine and paracrine signaling pathways. Hexarelin is used as a research tool in studies of cardiac peptide pharmacology, muscle metabolism, and ghrelin receptor biology.
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