TRH

Research dossier

TRH Thyrotropin (Protirelin)

Positioning

TRH Thyrotropin (Protirelin)

Thyrotropin-releasing hormone (TRH or Protirelin) is a research peptide composed of the tripeptide sequence pGlu-His-Pro-NH₂.

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Research DossierTRH

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SequencePyr-His-Pro

FormulaC16H22N6O4

Mol. Weight362.39 g/mol

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Sequence

Pyr-His-Pro

Molecular Formula

C16H22N6O4

Molecular Weight

362.39 g/mol

PubChem CID

638678

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Peptide Blends

CJC-1295 (no DAC), GHRP-2 10mg (Blend)

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CJC-1295 (no DAC), GHRP-6 10mg (Blend)

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CJC-1295 (no DAC), Ipamorelin 10mg (Blend)

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CJC-1295 (no DAC), Ipamorelin, GHRP-2 (Blend)

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Fragment, CJC-1295 (no DAC), Ipamorelin 12mg (Blend)

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Mod GRF, GHRP-2 10mg (Blend)

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Mod GRF, Ipamorelin 10mg (Blend)

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Mod GRF, Ipamorelin, GHRP-2 (Blend)

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Sermorelin, GHRP-2 10mg (Blend)

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Tesamorelin, CJC-1295 (no DAC), Ipamorelin 12mg (Blend)

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Tesofensine 500mcg (30 Capsules)

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Vial Kits

GHRP-6 (5mg x 10), CJC-1295 no DAC (5mg x 10)

BND-G6-5mgx10-CJC-5mgx10

GHRP-6 (5mg x 10), Ipamorelin (5mg x 10)

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Hexarelin (5mg x 10), CJC-1295 no DAC (5mg x 10)

BND-Hex-5mgx10-Mod-5mgx10

Description

Thyrotropin-releasing hormone (TRH or Protirelin) is a research peptide composed of the tripeptide sequence pGlu-His-Pro-NH₂. It functions as a hypothalamic regulatory peptide that modulates the pituitary secretion of thyrotropin (TSH) and prolactin by activating the TRH receptor, a Gq-coupled GPCR. This interaction stimulates phospholipase C, IP₃, and intracellular Ca²⁺ signaling cascades that are involved in the regulation of the hypothalamic-pituitary-thyroid axis. TRH is used in preclinical studies for neuroend**o**crine feedback, receptor coupling, and second-messenger signal transduction.

Lechan RM & Fekete C, Physiol Rev, 2004;84(1):109-134

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References

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