Ipamorelin 10mg

Ipamorelin is a synthetic pentapeptide growth hormone secretagogue (Aib-His-D-2-Nal-D-Phe-Lys-NH₂), acting as a selective agonist at the ghrelin receptor GHS-R1a. It stimulates the release of GH through Gq/PLC- and calcium-dependent signaling pathways, without influencing the secretion of prolactin or cortisol. Ipamorelin is used in research that investigates G-protein signaling transduction, pituitary regulation, and peptide-mediated endocrine modulation.

Ipamorelin is a short peptide sequence that can bind to the ghrelin/growth hormone secretagogue receptor. It is one of the most selective growth hormone (GH) secretagogues known, and laboratory studies have shown that it has no effect on ACTH, prolactin, follicle-stimulating hormone, luteinizing hormone, thyroid-stimulating hormone, or cortisol release [1]. Due to its high degree of specificity, Ipamorelin has been of interest in research both as a standalone therapy and as a model peptide to understand how selectivity in receptor binding is achieved.